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The signaling pathways in the GIT includes the complex enteric nervous system (ENS) that consist of two neural networks located in the submucosa layer and has pacemaker cells and controls i.e., motility via release of neurotransmitters based on the amino acid tryptophan associated neurotransmitter serotonin (5-HT: Serotonin, 5-hydroxytryptamine), dopamine and GABA
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Conclusion To make the next generation of metabolic drugs, we need to know more about how different cellular processes work together
The GIP receptor activation adds metabolic effects that pure GLP-1 agonists do not provide, including potential benefits for bone formation and gut motility that may actually buffer against certain gastrointestinal side effects
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Favorable Safety Profile AOD-9604 demonstrated a safety profile indistinguishable from placebo across over 900 human participants
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