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Individuals with type 2 diabetes treated with GLP-1s have demonstrated improvements in inflammatory signaling and mitochondrial redox balance, including reduced reactive oxygen species production, improved mitochondrial membrane potential, and increased oxygen consumption

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3.4 Adverse events Three subjects experienced intermittent diarrhea, bloating and nausea before the initiation of semaglutide treatment (timepoint 1), but the symptoms were not severe enough to warrant discontinuation of metformin therapy

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Such data may include AOM usage patterns and treatment persistence