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GLP-1 agonism: Emerging hypotheses and limitations While GLP-1 RAs hold therapeutic promise for increasing lifespan and reducing the morbidity of age-related illness through action on multiple organ systems, tissue-specific effects of GLP-1R agonism are possible
Severe stomach pain should be discussed with a clinician right away
There are some potential biases in these data that we need to be cautious about, but this gives us some valuable insights about the risk profile of these agents that can inform subsequent studies perhaps even a randomized controlled trial that can tease out the specific mechanisms and provide more conclusive evidence. Reduced risk overall GLP-1 receptor agonists have been approved in the United States to treat diabetes since 2005 and obesity since 2014
As with Mounjaro, the dose is increased gradually, so the monthly cost climbs over the first few months until you find a dose youre happy with, after which costs will stabilise
Because body composition, eating patterns, and health behaviors differ around the world, the authors emphasized the need to understand how these drugs work in more diverse populations
Professional society guidelines now recommend GLP therapy for cardiovascular risk reduction in patients with type 2 diabetes and established cardiovascular disease or multiple cardiac risk factors
