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Mechanism of Action (How DSIP Works) CNS Penetration: Crosses the blood-brain barrier, exerting central effects on sleep regulation [Graf 1981]

We also quantified metabolites involved in the most proximal stages of the glycolysis pathway, namely glucose-6-phosphate (G6P) and fructose-6-phosphate (F6P) ( Figures 5H, I)

Side-effect patterns are different by route

One thing to note is that the 1,000 mg group levels remained above baseline levels after the wash out

Gabapentin inhibits -amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats