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Acknowledgements and funding The authors work on gut-derived hormones and obesity-diabetes has been generously supported over many years by Diabetes UK, Invest Northern Ireland, the Irish Endocrine Society, Northern Ireland Department for the Economy, and Ulster University Strategic Funding

493 Lipid peroxides and their reactive aldehyde derivatives are the key factors in cardiometabolic disorders in obesity, with GPX4 playing a crucial role

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