In human URAT1/SLC22A12 (another OAT family member), the equivalent arginine, R477 URAT1 , has a direct role in substrate coordination, forming a hydrogen bond with the substrate urate
10.1038/nature10992 94 OzcanC.BienengraeberM.HodgsonD.MannD.TerzicA
Most published human data covers the parent CJC-1295 sequence, with several Phase 1 studies and one halted Phase 2 trial
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(2012), in their study, reported that 22 out of 33 male patients with severe idiopathic oligoasthenoteratozoospermia (OAT) of infertile couples whose partners had undergone at least one ICSI cycle, showed reduced sperm aneuploidy levels (assessed using fluorescent in situ hybridization performed on chromosomes X, Y, 13, 15, 16, 17, 18, 21 and 22) and improved sperm morphology after 3 months of treatment with LC 2 1 g/day, ALC 2 500 mg/day and cinnoxicam (a lipophilic NSAID) 1 30 mg/every 4 days [89]