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To further investigate the function of GSTM2 in hepatic lipid metabolism, we challenged the mice with HFD

21 Increasing glutathione levels Calcitriol, the active metabolite of vitamin D3, increases glutathione levels in the brain and appears to be a catalyst for glutathione production S-adenosylmethionine (SAMe), a co-substrate involved in methyl group transfer, has been shown to increase cellular glutathione content

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While our data suggest that production of NADPH by the TCA cycle is a key event in our proposed pathway, it is not yet clear how NADPH production corresponds to actual activity of the cyclegiven that metabolites can enter and exit the cycle at multiple points depending on nutritional conditionsnor how the cellular compartmentalization of NADPH production contributes to the transmission of the NADPH status to the ER