The most well-known GLP-1 medications available in the US in 2026 are Wegovy and Ozempic (both contain semaglutide), and Zepbound and Mounjaro (both contain tirzepatide, a dual GIP/GLP-1 agonist)
This observation led to the development of (Pro3)GIP, an analog of GIP with a glutamic-acid-to-proline substitution at position 3, improving glucose homeostasis and preventing weight gain in animal models of diabetes and obesity (Sparre-Ulrich et al., 2016)
Additional reference Lei L and Liu Y
Don't expect a pure GIP/glucagon drug for human use anytime soon
While metabolic changes (like improved sleep and energy) can often be felt within the first few weeks, significant changes in body compositionsuch as muscle gain and fat losstypically require 3 to 6 months of consistent therapy alongside proper nutrition
Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration