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These include mutations in genes such as: SNCA Alpha-synuclein gene PRKN Parkin RBR E3 Ubiquitin Protein Ligase PINK1 Gene PARK6 DJ-1 and PARK7 Gene LRRK2 It is believed that mutations in these genes can cause dysfunction and eventual death of dopamine-producing neurons through various mechanisms, including protein aggregation, mitochondrial dysfunction, and oxidative stress

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Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding

10.1111/j.1471-4159.2005.03425.x 224 PoliG.CheesemanK

Hold in mouth for 30-90 seconds before swallowing