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86 Notch signaling pathway Notch signaling, intimately involved in embryonic development and maintenance of multicellular organisms in adults, is activated by ligand-receptor interaction between adjacent cells, which leads to successive proteolytic cleavages and releases the notch intracellular domain (NICD)

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Results Participant characteristics Subjects with FM exhibited significantly higher pain ratings on a visual analogue scale (VAS), higher depression and anxiety scores on a Hospital Anxiety and Depression (HAD) Scale, and lower scores of the physical (SF-36 PCS) and mental (SF-36 MCS) components of the short form-36 health survey compared to HC (Table 1)

Lead toxicity Lead (Pb) toxicity is considered as the second most hazardous element after As, which comprises 0.002% of Earth's crust and it does not show any potential benefit in biological systems [19]

For superoxide anion, the main ROS, a first line of defense is represented by the enzyme superoxide dismutase, localized in the mitochondrial matrix

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