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Chan School of Public Health: "Vitamin B12." Inflammatory Bowel Diseases: "Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn's disease," "Vitamin B12 deficiency in inflammatory bowel disease: prevalence, risk factors, evaluation, and management." MedlinePlus: "Cyanocobalamin Injection." National Health Services: "Hydroxocobalamin," "Treatment -Vitamin B12 or folate deficiency anaemia Contents," "Vitamin B12." Nutrition Reviews: "How prevalent is vitamin B(12) deficiency among vegetarians?" Surgery for Obesity and Related Diseases: "Vitamin B12 deficiency in patients undergoing bariatric surgery: preventive strategies and key recommendations." The American Journal of Clinical Nutrition: "How common is vitamin B-12 deficiency?" The American Journal of Gastroenterology: "Vitamin B12 deficiency in untreated celiac disease." Top B12 Injections Who Get Them, How Quickly They Work Related Articles 22 Healthy Foods High in B VitaminsAny deficiency of B vitamins can lead to various health conditions

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An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme

Outcome focus: Does the evidence measure clinical pregnancy rates or live birth rates, not just surrogate markers