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calcium supplementation only if dietary intake is inadequate) [4] Nutritional assessment to ensure adequate protein intake during weight loss (minimum 1.0-1.2g/kg body weight) Encouragement of weight-bearing exercise and resistance training to maintain bone strength, in line with UK Chief Medical Officers' Physical Activity Guidelines Medication review to identify and address other factors affecting bone health Repeat fracture risk assessment in high-risk patients, with DXA scanning as clinically indicated based on NICE/NOGG guidance Patients experiencing weight loss faster than planned (particularly if exceeding 0.5-1kg per week sustained over several weeks) should be reviewed to ensure nutritional adequacy and consider whether treatment adjustment is appropriate

10.1007/s00216-012-6294-y Anal

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Several studies have primarily evaluated the changes in cardiovascular risk biomarkers upon the use of GLP-1 RAs

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The study involved researchers in the UCL Faculties of Brain Sciences, Population Health Sciences and Medical Sciences alongside colleagues in the Universities of Exeter, Oxford, North Carolina and Karolinska Institute, and was supported by Wellcome, the Medical Research Foundation and the National Institute for Health Research (NIHR)