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Compounded preparations also offer microdose flexibility that reduces side effect severity
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However, in patients intolerant to or for whom metformin is contraindicated, alternative monotherapy options include sodium-glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor agonists (GLP1 RAs), dipeptidyl peptidase-4 inhibitors, thiazolidinediones, alpha-glucosidase inhibitors, and sulfonylureas
Jejunal Gipr mRNA levels were unchanged in cold-stressed male and female WT mice, and not detected in DIRKO mice (Fig