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Effect on the GHRH System Both peptides depend on endogenous GHRH for their full GH-releasing effect, confirming the synergistic relationship between the two pathways

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Unlike many adult epithelial cancers that respond to immune checkpoint blockade, osteosarcoma exhibit features of immune exclusion and immune desertification, where cytotoxic T cells are either absent from the tumor core or physically segregated from malignant cells (5, 23)

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