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Factors that Deplete Glutathione Several factors can deplete glutathione levels, compromising the body's ability to detoxify and defend against oxidative stress: Acetaminophen (Paracetamol) : Widely used for pain relief and fever reduction, acetaminophen is a well-known depleter of glutathione

Vitamin C helps to keep glutathione in its "reduced" or active state, allowing it to continue neutralizing free radicals more effectively

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