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2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Supplementary Table S1

UPS dysfunction is closely associated with the pathological hallmarks of AD including the accumulation of A, formation of A plaques, and hyper-phosphorylation of Tau, which is the major component of intracellular neurofibrillary tangles

Discoloration: Any change from perfectly clear is a bad sign

doi:10.1189/jlb.0404248 16

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