Nature, 300:276-278
The new insight in the pathogenesis has given a number of new targets for intervention
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These drugs may lower inflammatory markers including C-reactive protein, TNF-, IL-6, and IL-1 through direct receptor activation and indirect metabolic improvements
Accordingly, the RIG-I pathway decreases, and the immune defense mechanism shifts to the activated TLR3, TLR7, TLR8, TLR9, MDA5, and UPS pathways found in neutrophil, macrophage, and dendritic cells
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