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These effects could result in gray hair and other noticeable symptoms

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Feb 2015;152(2):319-25

The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]

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Insufficient amounts may be produced in infants, in adolescents and in adults under certain physiological conditions