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8 The GlyNAC combination (glycine + NAC, addressing both rate-limiting precursors simultaneously) produced particularly robust results in a 16-week, placebo-controlled RCT in older adults: it corrected glutathione deficiency, reduced oxidative stress, improved mitochondrial fatty-acid oxidation, and enhanced physical performance measures including gait speed and the 6-minute walk test

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Five studies (38.7%) demonstrated high risks for overall bias, primarily due to deviations from intended interventions

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