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The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]

These compounds enhance liver and gallbladders roles by decreasing fat deposits and speeding up metabolism of fat and its removal

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Why NAD(+) Declines During Aging: It's Destroyed