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On February 7, 2025, Cardi and Pardison Fontaine released "Toot It Up"
When the 60 mg vial makes financial sense You are at a maintenance dose of 7.5 mg or higher (you will use the vial within the stability window) You have already titrated using smaller vials and know your target dose You are comfortable with reconstitution and precise syringe measurements You can store the vial properly for the entire duration When smaller vials make more sense You are just starting tirzepatide and do not know your dose yet You are microdosing at very low amounts (1-2.5 mg) You want to test a new vendor or batch before committing to a large purchase Your storage conditions are not ideal (unreliable refrigeration, travel) Syringe selection and measurement precision The syringe you use matters more than most people realize
Pearson-Stuttard J, Cheng YJ, Bennett J et al (2022) Trends in leading causes of hospitalisation of adults with diabetes in England from 2003 to 2018: an epidemiological analysis of linked primary care records
This results in a darker complexion
Common signs that inflammation is driving your symptoms Some gut signs are easy to spot