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They block acetylcholine and NMDA receptors, which has two effects: the first is that they synergize with dopaminergic agents, enhancing release and turnover of dopamine in the striatial neurons

Although applying it to the skin could help, the results might not show up immediately as they would with other approaches

BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial disagreement with mRNA levels

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For instance, those with high physical activity may benefit from slightly higher doses, whereas people with pre-existing medical conditions may need to lower the dosage accordingly

2009 Aug;57(6):695-702