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Some early studies in animals have shown a potential risk to foetal development, which is why current advice is to avoid use in pregnancy and stop treatment well in advance of trying to conceive

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An elevated resting heart rate can increase long-term cardiovascular risk, and regulators need robust data confirming that the metabolic benefits outweigh this potential downside

Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gomez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, et al