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Homocysteine can either be remethylated to methionine or metabolized to cysteine through a transsulfuration pathway requiring vitamin B 6
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Specifically, ATF-4 enhances stress resistance and promotes longevity in worms by upregulating the transsulfuration enzyme CTH-2, increasing hydrogen sulfide (H 2 S) production ( In mammalian cells, stress conditions lead to the upregulation of CHAC1 through the action of ATF4
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therefore, the anti-inflammatory effects of L-carnitine in fish require further study
