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If this explanation is valid, the same sequence of events shown in Figure 1 is expected with mutations or other factors that reduce mitochondrial energy production (or increase ROS production) making the neurons and glia more susceptible to excitotoxicity

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These outcomes occur without the side effects of traditional anti-inflammatory drugs or the risks of more aggressive procedures

Briefly, mice were housed individually in standard laboratory cages equipped with two bottles, one containing water and the other containing a solution of ethanol