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Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments

In our meta-analysis, L-carnitine significantly reduced total cholesterol and showed borderline significant reduction of LDL-C, while plasma HDL-C and triglycerides were not affected

One speculation is that although adipocytes have reduced GPX4, adipocytes may be similar to some tumor cells, which still have a high level of GSH in their cells, so that although adipocytes are in an overall oxidative stress condition, the remaining GPX4 from GSH is still needed to neutralize large amounts of ROS and remove some of the lipid peroxides, resulting in differentiated adipocytes that are not or less affected by ferroptosis (81)

Native GLP-1 has a short half-life of 12 min owing to rapid degradation by dipeptidyl peptidase-4 (DPP-4) [15]

Common side effects could include minor irritation at the application site, redness, or slight itching

China Life Sci