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In the absence of amino acids such as cystine, cells promote translation of ATF4 via the general control non-repressor 2 (GCN2) -eukaryotic initiation factor (eIF2a) signaling pathway, which promotes transcription of genes involved in amino acid metabolism and stress response, including SLC7A11, enabling cells to cope with amino acid starvation

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Lack of B12 can affect immune system

These oligomers associate with UBE2F and CUL5 to assemble a ternary complex, which enhances CUL5 neddylation