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Large-scale clinical trials with semaglutide (STEP 1) found that roughly 40% of total weight loss came from lean body mass (LBM), which is higher than the roughly 25% expected during typical physiological weight loss (the so-called "quarter fat-free mass rule")
Further studies on Melanotan 2 have revealed additional benefits, including enhanced weight loss due to appetite suppression and increased libido
& Heagerty, A
This strategy shows promise as an anti-tumor immunotherapy
Early clinical data suggests GI side effects are common but manageable
doi: 10.1001/jama.2019.2941 6 WenSNguyenTGongMYuanXWangCJinJet al
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