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Semaglutide and tirzepatide commonly cause gastrointestinal side effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort
[Article] [PubMed]64
It has an established safety profile and is prescribed by doctors across the country
While semaglutide targets the GLP-1 receptor, tirzepatide acts as a dual agonist (GLP-1 and GIP), which may influence the profile of adverse events
Common side effects include: Feeling sick (nausea) Vomiting Diarrhoea Constipation Indigestion or bloating These problems usually improve over time as your body becomes accustomed to the medicine
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More recent research has tested doses up to 7.2 mg and even 16 mg weekly, with greater weight loss but also increased gastrointestinal side effects
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