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Treatment selection should consider BMI, obesity-related complications, KOA severity, surgical candidacy, patient preference, local expertise, cost, and expected adherence (Sattari et al., 2024

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Compound identity at a glance Name: Retatrutide INN: LY3437943 Class: Triple incretin receptor agonist Structure: 39-amino-acid synthetic peptide Dosing interval: Once weekly (research protocols) Developer: Eli Lilly For the full molecular reference (molecular formula, molecular weight, CAS number and the 39-amino-acid sequence) see the Retatrutide molecular profile

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It acts as a growth hormone (GH) secretagogue stimulating levels of GH and insulin-like growth factor 1 (IGF-1), while preserving GH pulsatility

However, the clinical trial data does not support weight-based starting dose adjustments for retatrutide