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On the more skeptical side, tolerability at the highest weekly dose (1.2mg) may be less favorable and finding an optimized efficacy/safety profile as Metsera is doing could enhance the drugs competitive positioning
Food and Drug Administration (FDA) for chronic weight management in adults with obesity (BMI of 30 or higher) or overweight (BMI of 27 or higher) and at least one weight-related condition, such as type 2 diabetes, high blood pressure, or high cholesterol
Clinical studies have shown tirzepatide to produce greater average weight loss and glycemic improvement than semaglutide in comparable populations
Start With the End in Mind From the very first prescription, I work with patients to plan how theyll eventually transition off the medication
E.MeexR
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