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The Metabolic Profile of Down Syndrome Down syndrome is a complex metabolic and genetic disorder whose root cause, trisomy 21, is an extra copy of chromosome 21 [59]
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Oral glutathione supplements have historically shown poor bioavailability, and unlicensed intravenous glutathione infusions carry risks including infection and allergic reactions
10.1038/sj.thj.6200407 31 FrazerD
RNA extraction and RTqPCR Total RNA from cells was isolated via TRIzol (Takara, Otsu, Japan) and subsequently purified with chloroform/isopropanol/ethanol, and cDNA was synthesized via the PrimeScript RT reagent Kit (Takara) according to the manufacturers instructions and used as the template for qRTPCR
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