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Several studies have shown that tirzepatide reduces insulin resistance, improves glycemic control, and lowers inflammatory biomarkers, including C-reactive protein and IL-6 (46, 47)

The gastrointestinal tract rapidly degrades most plant-based peptide mimetics, and oral bioavailability data is rarely published

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Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and isoglycemic intravenous glucose