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Within that, the majority of our patients developed hypocarnitinemia within the first 39 months of initiating MAD

Certainty of evidence was high

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at the same time, changes in intracellular Ca 2+ lead to the opening of neuronal pannexin 1 channels to open and activate cystatinase 1, followed by the release of high mobility group box-1 protein and the activation of nuclear factor kappa-B signaling pathway in astrocytes (Figure 1B)

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