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The standard approach involves 250 to 500 micrograms per day via subcutaneous injection, with peri-lesional injection as an option for superficially accessible injuries such as Achilles tendinopathy or lateral epicondylitis

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These medications work by reducing appetite, increasing feelings of fullness, and slowing digestion, which helps decrease calorie intake and promotes sustainable weight loss

PMC 2635004

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For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%)