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PubMed laboratory research record [PMID: 21533514] PubMed record related to this compound for laboratory literature review
The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases 9,10,11 , though the reason for sex differences in this response remains unresolved
Ruxolitinib is particularly associated with the development of skin cancer, as 17.1% of patients on the therapy developed basal cell carcinoma or squamous cell carcinoma compared with 2.7% of patients on alternate available therapy for myelofibrosis (Figure 4)
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