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In this context, with the progression of the disease, there is an increase in the frequency and severity of episodes of mania and depression over the years, leading to an increase in the number of associated medical and psychiatric comorbidities 7 , with an imbalance between pro- and anti-inflammatory factors 8 , showing a reduction in neurotrophins 9 , and increased oxidative stress 10

However, if a patient is found to have low positive titers of paraneoplastic antibodies and suspicion is low for an occult cancer (eg, no weight loss or early satiety), repeat confirmatory testing at another laboratory should be done before embarking on an extensive search for malignancy

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At GoalBMI Wellness, peptide therapy discussions are focused on individualized wellness care and provider-guided treatment planning