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Unsolved mysteries: How does lipid peroxidation cause ferroptosis

Under physiological conditions, ROS are generated in the heart mainly from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX), and xanthine oxidase (XO) in small quantities [7, 8]

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The structure is what gives the peptide its specific function, and aggressive handling can physically damage that structurea process called denaturation

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