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What it may support
Furthermore, Figure 4D confirmed that H 2 O 2 increased the content of cellular ROS, while both targeting peptides obviously reduced the fluorescence intensity of the cellular ROS probe compared to that of GHK, especially RGD-GHK inhibited approximately 40% of ROS production
This complexity makes identifying and specifically targeting the most relevant pathways within this vast network difficult, as targeting a single oxidant or source may be insufficient and could potentially interfere with physiological redox signaling, given ROSs crucial dual roles as signaling molecules (as elaborated in Section 2.2) (Gualtieri et al., 2021
Gen.Physiol Biophys 2010;29(1):50-58
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPAR pathways
However, it is crucial to understand potential side effects and why they occur
