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Rather than directly activating GABA-A receptors, the peptide appears to maintain homeostasis of the entire GABA receptor complex, preventing the desensitization and compensatory changes that produce tolerance and dependence

When neurological symptoms are present, treatment should be initiated promptly and not delayed pending test results

PMID 16314912

Slow injection may minimize any stinging sensation associated with the compound

Calcium may help prevent low bone density

TB-500 has demonstrated neuroprotective effects in experimental models of neurological injury, and both peptides may have potential applications in promoting recovery following various forms of neurological trauma