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Five studies 14,21,33,35,36 , were identified which evaluated the effect of GLP-1-based therapies on IMT using longitudinal designs

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This study demonstrated that cultured hepatocytes treated either with a precursor of GSH, such as L-cysteine or N-acetylcysteine, or with its soluble ethyl ester form, boosts the levels of cellular GSH, which upregulates CYP27A1, CYP27B1, and VDR but downregulates CYP24A1