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Phase 2 trials published in the New England Journal of Medicine showed participants losing an average of 24.2% of their body weight at the 12mg weekly dose over 48 weeks

The most important thing is to find a solution that is sustainable and works for you in the long term

Severe vomiting that prevents you from keeping fluids down, signs of dehydration, severe abdominal pain, or persistent high fever should be reported to your healthcare provider right away

According to Yucca Health's safety information pages, GLP-1 medications like semaglutide and tirzepatide have important contraindications: Do not use if: You or a family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) You have had a severe allergic reaction to semaglutide, tirzepatide, or any ingredients in the formulation You are pregnant, planning to become pregnant, or breastfeeding (GLP-1 medications are not recommended during pregnancy or breastfeeding) Use with caution and close medical supervision if you have: History of pancreatitis or pancreas problems Kidney problems or history of kidney disease Severe gastrointestinal issues such as gastroparesis Type 2 diabetes with history of diabetic retinopathy (semaglutide specifically) Are taking other medications including insulin or sulfonylureas (increased risk of hypoglycemia) The provider reviewing your intake will screen for these factors and may decline to prescribe if contraindications are present or request additional information before making a determination

The combination is uncommon enough that specific guidance is limited