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The field is evolving rapidly, and what was cutting-edge five years ago may be outdated by the time newer compounds complete their clinical programs

They establish biological mechanisms in controlled settings but do not constitute proof of specific human outcomes

GCL is composed of a catalytic (GCLC, Mr ~73 kDa) and a modifier (GCLM, Mr ~31 kDa) subunit [32] (summarized in Fig

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