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Type 2 diabetes mellitus (T2DM) would lead to bone fragility, high risk of fracture, poor bone repair and other bone-related diseases
The trial supporting Wegovy's higher-dose presentation ran 72 weeks in 1,407 participants and reported 18.7% with semaglutide 7.2 mg versus 15.6% with 2.4 mg and 3.9% with placebo results that led to the approval of the 7.2 mg maximum maintenance dosage now reflected in the labeling
The problem is not the medication alone
The FDA estimates that 10 deaths and 100 hospitalizations may be linked to the use of compounded GLP-1RAs
~150-fold parent signal reduction at 3 h
That pattern is consistent with prescribing information describing gastrointestinal adverse reactions during escalation
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