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In patients with chronic heart disease, administration of L-carnitine over 12 months led to attenuation of left ventricular dilatation and prevented ventricular remodeling while reducing incidence of chronic heart failure and death [125]

It is postulated that riboflavin induces NO-mediated vasodilatation, resulting in hypertension relief, through stimulation of the conversion of homocysteine and its subsequent impact on the L-arginine/NO pathway 125 (Fig