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Moreover, combining both arms of the drug is justified best in this case by our research question, which investigates the overall effect of the GLP-1 receptor agonists in PD treatment, not to compare the effect of different doses of one drug in this drug family

Reference: Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHS

Off-cycle periods are commonly described in protocol summaries as a way to reduce the risk of receptor desensitization with sustained ghrelin-receptor stimulation