Straight on
GLP-1R is abundantly expressed in the pancreas and CNS
In SUSTAIN-6, nearly 30% of patients had previous documented DRP, with 6% proliferative DRP
However, because they are not yet FDA-approved for medical use, access is typically through compounding pharmacies or clinical research settings
In the comprehensive research program to solve this challenge, the strategy was to keep the peptide as similar to liraglutide and endogenous GLP-1 as possible, to avoid unnecessary risks in terms of immunogenicity
Unlike proprietary systems, open-weight models can be pulled from public repositories, adapted, and hosted on private servers, a characteristic that has allowed Chinese-origin models to flow into U.S