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However, the SGLT2i treated cohort were less likely to develop heart failure (RR 0.44 [95% CI 0.23, 0.83] p =0.0092), CKD (RR 0.49 [95% CI 0.28, 0.86] p =0.0118) and be hospitalised for any cause (RR 0.59 [95% CI 0.46, 0.76] p 0.0001) when compared with the GLP-1 RA treated cohort

Led by scientists from the United States, Brazil, Iran, and Israel, the study highlights that while GLP-1 receptor agonists can be beneficial for individuals with hyperdopaminergia (elevated dopamine activity), they may have adverse effects on those with hypodopaminergia (reduced dopamine function)

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The peptide is a five-residue chain capped with a C-terminal amide

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