The relevant caution from the paper's own discussion is that FOXO4 has a normal role in DNA-damage repair and Foxo4-knockout mice handle acute damage badly, which is why the authors explicitly ruled out permanent FOXO4 inhibition
Aroda, M.D., from Brigham and Women's Hospital in Boston, and colleagues randomly assigned adults with type 2 diabetes inadequately controlled with diet and exercise to receive once-weekly subcutaneous cagrilintide 2.4 mg plus semaglutide 2.4 mg, cagrilintide 1.0 mg plus semaglutide 1.0 mg, or placebo for 40 weeks (62, 63, and 64 participants, respectively)
Likewise, subjective improvement of hangover symptoms wasn't as pronounced, meaning other factors may still play into a hangover
Adriaenssens AE, Biggs EK, Darwish T et al (2019) Glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus regulate food intake
Health risks drive Canada's peptide crackdown In Canada, injectable peptides are classified as prescription drugs and must receive authorisation from Health Canada before they can be sold
200mg Alpha-Lipoic Acid (ALA) per daily serving, in both R- and S-ALA forms