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Long-acting GLP-1 receptor agonists like semaglutide and tirzepatide appear to exert a more pronounced inhibitory effect on gallbladder contraction compared to short-acting agents like exenatide

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For example, in a study by Mikhalkova et al

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FDA therefore identified a theoretical carcinogenic concern where chronic exposure activates telomerase or extends telomeres in cells capable of malignant transformation

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